Exploration of the Zinc Finger Motif in Controlling Activity of Matrix Metalloproteinases
نویسندگان
چکیده
منابع مشابه
Exploration of the Zinc Finger Motif in Controlling Activity of Matrix Metalloproteinases
Discovering ways to control the activity of matrix metalloproteinases (MMPs), zinc-dependent enzymes capable of degrading extracellular matrix proteins, is an important field of cancer research. We report here a novel strategy for assembling MMP inhibitors on the basis of oligopeptide ligands by exploring the pattern known as the zinc finger motif. Advanced molecular modeling tools were used to...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2014
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp5088702